Speaker
Description
Transdermal drug delivery systems (TDDS) using nanobiotechnologies enhance treatment effectiveness by bypassing gastrointestinal metabolism, allowing for better drug targeting and improved outcomes. This study describes the preparation of cellulose acetate (CA)-based nanofibrous membranes as sophisticated biomaterials enabled with Temozolomide (TMZ), an anticancer drug commonly used in treating brain tumours, including glioblastoma. Cellulose acetate (CA) nanofibers loaded with TMZ were synthesized by electrospinning using CA at a constant concentration of 17% (w/v) and with different TMZ loadings (5 mg, 10 mg and 15 mg). Electrospun TMZ–CA nanofiber membranes were comprehensively characterized by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and energy-dispersive X-ray spectroscopy (EDX). SEM analysis revealed that the fibers were smooth and bead-free, indicating successful electrospinning. FTIR and UV spectroscopy analysis confirmed that TMZ retained its stability and molecular integrity within the cellulose acetate (CA) matrix following fabrication. In-vitro drug release profiles using phosphate-buffered saline (PBS) showed that the controlled drug-releasing behaviours from membranes by loading 10mg and 15mg TMZ from these membranes are in the optimal range. Also, sessile drop contact angle studies showed hydrophobicity (angles above 90°), indicating continued drug release. The study illustrates the possibilities of using functional nanomaterials, in this case, electrospun TMZ-loaded CA nanofibers. They retain the stability of the drug, sustain release properties, and provide appropriate surface characteristics. This study highlights the potential of TDDS in cancer therapy, paving the way for future in-vivo experiments and clinical applications of nanotechnology-based implantable devices.
