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In human body tissue, post-operative adhesion spontaneously develops as a result of wound healing. Adhesion can impair organ and tissue function and, in certain situations, endanger the patient's life. One in three individuals who have surgery on their abdomen may require continuation care due to adhesion. Physical barriers can hinder adhesion and have a major impact, according to several studies on chemical compounds. In order to prevent digestive post-operative adhesion, this study attempts to synthesize and describe the alginate-chitosan membrane as a potential physical barrier. membrane produced by mixing solutions of alginate and chitosan at various concentrations until the mixture is homogenous, after which it is dried and submerged in CaCl2 solution. SEM, FTIR, swelling, degradation, MTT Assay, and water contact tests are then used to evaluate the final membrane. According to the characterization, the variation with the best alginate-chitosan membrane properties is the 1.5% concentration, which has 73.36% cell viability, 90.75% swelling rate, and 96.71% disintegration rate on the tenth day. Alginate-chitosan membranes have the ability to act as a physical barrier to stop digestive post-operation adhesion, according to this research.
Key Words : alginate, chitosan, membrane, physical barrier, anti adhesion
