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Description
Quercetin (Que) is a type of flavonoid used as potential phytochemical in treating chronic diseases due to its anti-inflammatory, antioxidant and other therapeutic effects. It is commonly taken via oral and injection approaches. However, its curative efficacy is limited by its low aqueous solubility, extensive first pass metabolism and resultant low availability. In this study, an electrospun Que-loaded poly (ε caprolactone) (Que/PCL) nanofibrous was fabricated as a potential bioactive implantable drug. The prepared nanofibers were characterized by scanning electron microscopy (SEM), Fourier trans-form infrared spectroscopy (FTIR), mechanical test, and thermogravimetric analysis (TGA). In vitro release of Que from the nanofibers was studied in a simulated physiological condition using ultraviolet-visible (UV-vis) spectroscopy. The morphological and mechanical studies showed successful formation of nanofibers with bead-less, randomly interconnected uniform structure and porosity appropriate to be used as drug delivery vehicle. Que re-lease study indicated the highest amount of Que release within 180 min period, and sustained release until day-21. Overall, the fabricated nanofibers have provided desired properties for implantable drug delivery application.
